Biodistribution control of lipophilic drugs with lipid carrier system.
نویسندگان
چکیده
منابع مشابه
Evaluation of the carrier potential for the lipid dispersion system with lipophilic compound.
KW-3902 (a newly synthesized adenosine A(1)-receptor antagonist) has potent diuretic and renal protective activities and was formulated in lipid dispersion systems, i.e., lipid emulsions and liposomes. The objective of the present study was to evaluate the carrier potential of these lipid dispersion systems, which is explained here as the ability of the formulation to retain the drug in its dis...
متن کاملLipid-based formulations for oral delivery of lipophilic drugs.
In the last decade there has been a growing interest in lipid-based formulations to deliver challenging compounds such as lipophilic drugs. Following a brief clarification of the nomenclature, this review stresses the different mechanisms of how lipid-based excipients and formulations interact with the absorption process. Case studies are presented in which enhanced bioavailability was demonstr...
متن کاملNovel Lipid Carriers for Oral Delivery of Lipophilic Drugs
Most of the new chemical entities discovered today are highly lipophilic in nature and show poor solubility and membrane permeability resulting in poor oral bioavailability. The need for an effective carrier system led to the development of novel lipid based carriers for enhancing the solubility and bioavailability of such drugs Lipids are fatty acids and their derivatives, and substances relat...
متن کاملEmulsion forming drug delivery system for lipophilic drugs.
In the recent years, there is a growing interest in the lipid-based formulations for delivery of lipophilic drugs. Due to their potential as therapeutic agents, preferably these lipid soluble drugs are incorporated into inert lipid carriers such as oils, surfactant dispersions, emulsions, liposomes etc. Among them, emulsion forming drug delivery systems appear to be a unique and industrially fe...
متن کاملNanostructured lipid carrier-loaded hyaluronic acid microneedles for controlled dermal delivery of a lipophilic molecule
Nanostructured lipid carriers (NLCs) were employed to formulate a lipophilic drug into hydrophilic polymeric microneedles (MNs). Hyaluronic acid (HA) was selected as a hydrophilic and bioerodible polymer to fabricate MNs, and nile red (NR) was used as a model lipophilic molecule. NR-loaded NLCs were consolidated into the HA-based MNs to prepare NLC-loaded MNs (NLC-MNs). A dispersion of NLCs was...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Drug Delivery System
سال: 1995
ISSN: 1881-2732,0913-5006
DOI: 10.2745/dds.10.153